How much weight can you lose on GLP-1 medications?

Clinical trials show average weight loss of 15-20% of body weight with semaglutide (Wegovy/Ozempic) and 20-25% with tirzepatide (Mounjaro/Zepbound) over 12-18 months. Individual results vary based on starting weight, dosage, diet, and exercise.

Are GLP-1 medications better than diet and exercise alone?

For significant weight loss, GLP-1 medications typically produce greater results than diet and exercise alone. Studies show diet/exercise averages 5-10% weight loss, while GLP-1s average 15-25%. However, GLP-1s work best when combined with lifestyle changes, and the goal should be sustainable habits, not just medication.

What happens when you stop taking GLP-1 medications?

Most people regain weight after stopping GLP-1 medications, especially if lifestyle habits haven't changed. Studies show about 2/3 of weight lost is regained within a year of stopping. This is why we focus on building sustainable habits and tracking body composition to preserve muscle during weight loss.

How do GLP-1s compare to bariatric surgery?

Bariatric surgery typically produces more weight loss (25-35%) and is more durable long-term. However, it's invasive, irreversible, and carries surgical risks. GLP-1s offer significant weight loss (15-25%) without surgery, but require ongoing use to maintain results. GLP-1s are often considered before surgery or for those who don't qualify.

How much does GLP-1 weight loss cost at Moonshot?

The Weight Loss program at Moonshot Medical is $405/month, which includes the GLP-1 medication (semaglutide or tirzepatide), medical oversight, required labs and diagnostics, body composition tracking with DEXA, and dosing adjustments. We also offer a $105/month Prescription Program if your insurance covers the medication.

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GLP-1 VS OTHER WEIGHT LOSS METHODS

How do medications like semaglutide and tirzepatide compare to diet, exercise, surgery, and other approaches? Here's an evidence-based breakdown.

AVERAGE WEIGHT LOSS BY METHOD

Diet + Exercise

5-10%

Semaglutide

15-20%

Tirzepatide

20-25%

Bariatric Surgery

25-35%

Based on clinical trial data. Individual results vary.

DETAILED COMPARISON

GLP-1s vs Diet & Exercise Alone

Diet & Exercise

• Average 5-10% weight loss
• High relapse rate (most regain)
• No medication side effects
• Builds sustainable habits
• No ongoing cost (gym optional)
• Requires significant willpower

GLP-1 Medications

• Average 15-25% weight loss
• Weight regain if stopped
• Possible GI side effects
• Reduces appetite naturally
• Ongoing medication cost
• Works with your biology

Bottom line: GLP-1s produce significantly more weight loss, but work best when combined with diet and exercise. The medication makes it easier to stick to healthy habits by reducing hunger and cravings.

GLP-1s vs Bariatric Surgery

Bariatric Surgery

• 25-35% average weight loss
• More durable long-term
• One-time procedure
• Surgical risks (1-2% complication)
• Irreversible (most types)
• Strict dietary requirements after

GLP-1 Medications

• 15-25% average weight loss
• Requires ongoing use
• Non-invasive
• GI side effects possible
• Fully reversible (stop anytime)
• No surgical recovery

Bottom line: Surgery produces more weight loss and is more durable, but GLP-1s offer significant results without the risks and permanence of surgery. Many patients try GLP-1s before considering surgery.

GLP-1s vs Other Weight Loss Medications

Medication	Avg Weight Loss	How It Works
Semaglutide (Wegovy)	15-20%	GLP-1 receptor agonist
Tirzepatide (Zepbound)	20-25%	GLP-1 + GIP dual agonist
Phentermine	5-10%	Appetite suppressant (stimulant)
Contrave	5-8%	Naltrexone + bupropion
Orlistat (Alli)	3-5%	Fat absorption blocker

THE REAL QUESTION: SUSTAINABILITY

Every weight loss method has one thing in common: the challenge is keeping the weight off.

GLP-1 medications produce impressive results, but studies show most people regain weight after stopping. This isn't a failure of the medication—it reflects the biology of weight regulation.

Our approach at Moonshot focuses on two things:

1. Preserve Muscle

Rapid weight loss often means muscle loss. We use DEXA scans to track body composition and ensure you're losing fat, not muscle. Muscle preservation is critical for metabolic health and maintaining results.

2. Build Habits

The medication makes it easier to eat less. We help you use that window to build sustainable nutrition and exercise habits so you're not dependent on the medication forever.

GLP-1 WEIGHT LOSS AT MOONSHOT

Full Program

$405/mo

• GLP-1 medication included
• Medical oversight
• Required labs & diagnostics
• DEXA body composition tracking
• Dosing adjustments

Prescription Only

$105/mo

• Medical oversight
• Rx sent to your pharmacy
• Good if insurance covers GLP-1
• Required labs & check-ins
• Dosing guidance

COMMON QUESTIONS

Who is a good candidate for GLP-1 medications?

Generally, patients with BMI 30+ (or 27+ with weight-related conditions) who haven't achieved goals with diet and exercise alone. We evaluate each patient individually based on health history, labs, and goals.

What are the side effects of GLP-1 medications?

Most common are GI-related: nausea, constipation, diarrhea—especially when starting or increasing dose. These typically improve over time. We start with low doses and titrate slowly to minimize side effects.

Semaglutide vs Tirzepatide—which is better?

Tirzepatide (dual GLP-1/GIP agonist) shows slightly higher weight loss in trials, but both are effective. The best choice depends on individual response, side effects, and availability. We can discuss options during your consultation.

READY TO EXPLORE YOUR OPTIONS?

Start with a consultation. We'll review your health history and discuss whether GLP-1 therapy is right for you.

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