Medical Services
NAD+ Therapy
Restore the coenzyme your cells need to produce energy, repair DNA, and regulate aging. $60/shot, subcutaneous, 5 minutes. A fraction of what IV drip clinics charge.
Medically reviewed by Missy Zammichieli, DNP, APRN, FNP-BC · April 1, 2026
Book NAD+ Injection
WHAT IS NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell. It is not a supplement trend or a vitamin — it is required for the most fundamental metabolic processes that keep you alive.
NAD+ levels decline approximately 50% by age 60 (Massudi et al., 2012). This decline correlates directly with reduced energy, slower recovery, impaired cognitive function, and the metabolic dysfunction that characterizes aging.
The decline happens because CD38 — an enzyme that consumes NAD+ — increases with chronic inflammation as you age, while PARP enzymes consume more NAD+ to repair accumulating DNA damage. The result is a supply-demand mismatch that accelerates with every passing decade.
What NAD+ Does in Your Body:
- • Mitochondrial energy production — drives ATP synthesis via the electron transport chain
- • DNA repair — PARP enzymes consume NAD+ to fix single-strand breaks (tens of thousands per cell per day)
- • Sirtuin activation — SIRT1-7 regulate aging, inflammation, and metabolism; all are NAD+-dependent
- • Cellular signaling — calcium homeostasis, circadian rhythm regulation, immune function
DELIVERY METHODS COMPARED
Not all NAD+ delivery is created equal. The molecule is the same — the difference is bioavailability, time, and cost.
SubQ Injection
$60/shot
- Time: 5 minutes
- Bioavailability: Near-complete — bypasses gut entirely
- Frequency: 1-2x/week (loading), then weekly or biweekly
- Bottom line: Best cost-to-bioavailability ratio. Same molecule as IV, without the 4-hour chair time or the markup.
IV Drip
$250-1,000+/session
- Time: 2-4 hours per session
- Bioavailability: 100% — direct intravenous delivery
- Frequency: Weekly or biweekly
- Bottom line: Highest bioavailability, but the time and cost make consistent protocols impractical for most people. You are paying for IV lounge overhead.
Oral NMN/NR Supplements
$40-80/month
- Time: Daily pill or powder
- Bioavailability: Approximately 2-5% — most is degraded in the gut before reaching cells
- Frequency: Daily
- Bottom line: Convenient but poor absorption. The amount of NAD+ precursor that actually reaches your bloodstream is a fraction of what injections deliver. Read our NAD+ vs NMN comparison.
WHO BENEFITS MOST FROM NAD+
NAD+ is not a magic bullet — but for the right candidates, the improvement in energy, recovery, and cognitive function is measurable.
Chronic Fatigue and Low Energy
If your mitochondria are starved for NAD+, ATP production drops. Patients with persistent fatigue that blood work has not explained often respond well to NAD+ therapy. It addresses the cellular energy deficit directly.
Slow Exercise Recovery
Athletes and active adults who notice recovery taking longer than it used to. NAD+ supports the repair pathways that clear metabolic waste and rebuild damaged tissue after training. Particularly popular with rehab and CrossFit athletes.
Brain Fog and Cognitive Decline
Neurons are among the most energy-demanding cells in your body. When NAD+ drops, cognitive function follows — poor focus, slower processing, memory lapses. Restoring NAD+ levels supports neuronal energy metabolism and sirtuin-mediated neuroprotection.
Adults 40+ With Age-Related Decline
NAD+ decline accelerates after 40. If you are noticing a general downward trend in energy, sleep quality, recovery, and vitality that does not have a specific diagnosis, depleted NAD+ is a physiological explanation worth addressing.
Hormone Therapy Patients
NAD+ supports the metabolic pathways that hormones activate. Patients on TRT or other hormone optimization protocols often see compounding benefits from adding NAD+ — the hormones signal your body to build and repair, and NAD+ provides the cellular fuel to execute.
Post-Illness Recovery
Viral infections and chronic illness deplete NAD+ reserves as your immune system and DNA repair machinery consume it at elevated rates. NAD+ therapy can help restore baseline cellular function during and after recovery.
STACKING NAD+ WITH OTHER THERAPIES
NAD+ is not a standalone treatment at Moonshot. It is a building block that amplifies other optimization protocols. Here is how the combinations work.
NAD+ + TRT
Testosterone signals your body to build muscle, burn fat, and maintain bone density. NAD+ fuels the mitochondrial energy production those processes depend on. Without adequate NAD+, you may be leaving TRT results on the table — your cells get the signal but lack the fuel to execute.
Learn about TRT at Moonshot →NAD+ + BPC-157
BPC-157 promotes angiogenesis (new blood vessel formation) and tissue healing at injury sites. NAD+ supports the cellular energy and DNA repair machinery those healing processes require. Together, you get faster and more complete tissue repair — popular with athletes managing chronic injuries.
See peptide therapy options →NAD+ + GLP-1
GLP-1 medications drive significant metabolic shifts — weight loss, improved insulin sensitivity, reduced inflammation. NAD+ supports the mitochondrial function and metabolic pathways that GLP-1 is activating, helping your cells keep up with the metabolic demand of rapid body composition changes.
Learn about medical weight loss →NAD+ + Sermorelin
Sermorelin stimulates growth hormone release, which drives recovery, sleep quality, and body composition. NAD+ activates SIRT1, which regulates growth hormone signaling pathways. The combination creates a synergistic effect on recovery and anti-aging — growth hormone handles the rebuilding, NAD+ handles the energy and repair infrastructure.
Learn about Sermorelin →TRANSPARENT PRICING
Single Injection
$60/shot
- Subcutaneous, clinical dose
- Administered by medical staff
- No membership required
- No contracts, pay per visit
3-Month Protocol
$600/bundle
- 12 injections (1x/week for 12 weeks)
- Save $120 vs. per-visit pricing
- Loading phase + maintenance
- Provider-guided protocol
6-Month Protocol
$1,080/bundle
- 24 injections (1x/week for 24 weeks)
- Save $360 vs. per-visit pricing
- Full optimization protocol
- Best long-term value
Members: Hormone optimization and weight loss members get 1 vitamin injection per month included in their plan. NAD+, B12, Vitamin C, and other vitamin injections all qualify. Additional injections are $60 each.
Compare: IV NAD+ drips in the Chicago area typically run $250-500 for a single session, with some boutique clinics charging $750-1,000+. At Moonshot, a full 8-session loading protocol (2x/week for 4 weeks) costs $480 total — less than a single IV session at most competitors.
COMMON QUESTIONS
How much do NAD+ injections cost at Moonshot?
$60 per injection. No membership required, no contracts. Hormone optimization members get 1 vitamin injection per month included. Compare that to $250-1,000+ for a single IV NAD+ session at most Chicago-area providers.
What is the difference between SubQ injections and IV drips?
Both deliver NAD+ directly to the bloodstream. IV drips take 2-4 hours and cost $250-1,000+ due to infusion center overhead. Subcutaneous injections take 5 minutes, deliver clinical doses with near-complete bioavailability, and cost $60 at Moonshot. The molecule does not know how it got into your bloodstream.
How often should I get NAD+ injections?
A typical protocol starts with 1-2 injections per week for 2-4 weeks (loading phase), then transitions to weekly or biweekly maintenance. Some patients do monthly maintenance long-term. Your provider adjusts the schedule based on your goals and response.
Why not just take oral NMN or NR supplements?
Oral NAD+ precursors like NMN and NR have poor bioavailability — approximately 2-5% survives gut metabolism to reach your cells. Injectable NAD+ bypasses digestion entirely, delivering the full clinical dose to the bloodstream. For a deeper comparison, read our NAD+ vs NMN guide.
Can I combine NAD+ with TRT or peptide therapy?
Yes — and it is one of the most common combinations we see. NAD+ supports the metabolic pathways that hormones and peptides activate. Patients on testosterone optimization or peptide therapy often report compounding benefits from adding NAD+.
Is NAD+ therapy safe?
NAD+ injections are generally well-tolerated. The most common side effects are temporary flushing, warmth, or mild nausea — these resolve within minutes. All injections are administered under medical oversight by a board-certified nurse practitioner who reviews your health history and medications before starting any protocol.
RESTORE YOUR CELLULAR ENERGY
$60 per injection. Medical oversight. 5 minutes in and out. Park Ridge, IL.
542 Busse Hwy, Park Ridge, IL 60068 · (224) 435-4280 · No referral needed